Severe neurologic syndrome associated with Middle East respiratory syndrome corona virus (MERS-CoV)
Identifieur interne : 000916 ( Main/Exploration ); précédent : 000915; suivant : 000917Severe neurologic syndrome associated with Middle East respiratory syndrome corona virus (MERS-CoV)
Auteurs : Y. M. Arabi ; A. Harthi [Arabie saoudite] ; J. Hussein [Arabie saoudite] ; A. Bouchama [Arabie saoudite] ; S. Johani [Arabie saoudite] ; A. H. Hajeer [Arabie saoudite] ; B. T. Saeed [Arabie saoudite] ; A. Wahbi [Arabie saoudite] ; A. Saedy [Arabie saoudite] ; T. Aldabbagh [Arabie saoudite] ; R. Okaili [Arabie saoudite] ; M. Sadat [Arabie saoudite] ; H. Balkhy [Arabie saoudite]Source :
- Infection [ 0300-8126 ] ; 2015.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Arabie saoudite, Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification), Humains, Imagerie par résonance magnétique, Infections à coronavirus (anatomopathologie), Infections à coronavirus (diagnostic), Infections à coronavirus (virologie), Maladies du système nerveux (anatomopathologie), Maladies du système nerveux (diagnostic), Maladies du système nerveux (virologie), Mâle, Sujet âgé.
- MESH :
- anatomopathologie : Infections à coronavirus, Maladies du système nerveux.
- diagnostic : Infections à coronavirus, Maladies du système nerveux.
- isolement et purification : Coronavirus du syndrome respiratoire du Moyen-Orient.
- virologie : Infections à coronavirus, Maladies du système nerveux.
- Adulte d'âge moyen, Arabie saoudite, Humains, Imagerie par résonance magnétique, Mâle, Sujet âgé.
- Wicri :
- geographic : Arabie saoudite.
English descriptors
- KwdEn :
- Aged, Coronavirus Infections (diagnosis), Coronavirus Infections (pathology), Coronavirus Infections (virology), Humans, Magnetic Resonance Imaging, Male, Middle Aged, Middle East Respiratory Syndrome Coronavirus (isolation & purification), Nervous System Diseases (diagnosis), Nervous System Diseases (pathology), Nervous System Diseases (virology), Saudi Arabia.
- MESH :
- geographic : Saudi Arabia.
- diagnosis : Coronavirus Infections, Nervous System Diseases.
- isolation & purification : Middle East Respiratory Syndrome Coronavirus.
- pathology : Coronavirus Infections, Nervous System Diseases.
- virology : Coronavirus Infections, Nervous System Diseases.
- Aged, Humans, Magnetic Resonance Imaging, Male, Middle Aged.
Abstract
Since the identification of the first case of infection with the Middle East respiratory syndrome corona virus (MERS-CoV) in Saudi Arabia in June 2012, the number of laboratory-confirmed cases has exceeded 941 cases globally, of which 347 died. The disease presents as severe respiratory infection often with shock, acute kidney injury, and coagulopathy. Recently, we observed three cases who presented with neurologic symptoms. These are so far the first reported cases of neurologic injury associated with MERS-CoV infection.
Data was retrospectively collected from three patients admitted with MERS-CoV infection to Intensive Care unit (ICU) at King Abdulaziz Medical City, Riyadh. They were managed separately in three different wards prior to their admission to ICU.
The three patients presented with severe neurologic syndrome which included altered level of consciousness ranging from confusion to coma, ataxia, and focal motor deficit. Brain MRI revealed striking changes characterized by widespread, bilateral hyperintense lesions on T2-weighted imaging within the white matter and subcortical areas of the frontal, temporal, and parietal lobes, the basal ganglia, and corpus callosum. None of the lesions showed gadolinium enhancement.
CNS involvement should be considered in patients with MERS-CoV and progressive neurological disease, and further elucidation of the pathophysiology of this virus is needed.
The online version of this article (doi:10.1007/s15010-015-0720-y) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1007/s15010-015-0720-y
PubMed: 25600929
PubMed Central: 4521086
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000074
- to stream Pmc, to step Curation: 000074
- to stream Pmc, to step Checkpoint: 000310
- to stream PubMed, to step Corpus: 000643
- to stream PubMed, to step Curation: 000643
- to stream PubMed, to step Checkpoint: 000629
- to stream Ncbi, to step Merge: 000435
- to stream Ncbi, to step Curation: 000435
- to stream Ncbi, to step Checkpoint: 000435
- to stream Main, to step Merge: 000918
- to stream Main, to step Curation: 000916
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Severe neurologic syndrome associated with Middle East respiratory syndrome corona virus (MERS-CoV)</title><author><name sortKey="Arabi, Y M" sort="Arabi, Y M" uniqKey="Arabi Y" first="Y. M." last="Arabi">Y. M. Arabi</name><affiliation><nlm:aff id="Aff1">Intensive Care Department, MC-1425, Respiratory Services, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center (KAIMRC), P.O. Box 22490, Riyadh, 11426 Kingdom of Saudi Arabia</nlm:aff><wicri:noCountry code="subfield">11426 Kingdom of Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Harthi, A" sort="Harthi, A" uniqKey="Harthi A" first="A." last="Harthi">A. Harthi</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Neuro Physiology Services, Neurology Division, Department of Medicine, King Abdulaziz Medical City, Riyadh, 11426 Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Neuro Physiology Services, Neurology Division, Department of Medicine, King Abdulaziz Medical City, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Hussein, J" sort="Hussein, J" uniqKey="Hussein J" first="J." last="Hussein">J. Hussein</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Neuro Radiology Section, Medical Imaging Department, King Abdulaziz Medical City, Riyadh, 11426 Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Neuro Radiology Section, Medical Imaging Department, King Abdulaziz Medical City, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Bouchama, A" sort="Bouchama, A" uniqKey="Bouchama A" first="A." last="Bouchama">A. Bouchama</name><affiliation wicri:level="1"><nlm:aff id="Aff4">Intensive Care Unit, Experimental Medicine Department, King Abdullah International Medical Research Center (KAIMRC), King Abdulaziz Medical City, Riyadh, 11426 Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Unit, Experimental Medicine Department, King Abdullah International Medical Research Center (KAIMRC), King Abdulaziz Medical City, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Johani, S" sort="Johani, S" uniqKey="Johani S" first="S." last="Johani">S. Johani</name><affiliation wicri:level="1"><nlm:aff id="Aff5">Microbiology, Pathology and Laboratory Medicine, King Abdulaziz Medical City, Riyadh, 11426 Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Microbiology, Pathology and Laboratory Medicine, King Abdulaziz Medical City, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Hajeer, A H" sort="Hajeer, A H" uniqKey="Hajeer A" first="A. H." last="Hajeer">A. H. Hajeer</name><affiliation wicri:level="1"><nlm:aff id="Aff6">Basic Medical Sciences, Microbiology, Pathology and Laboratory Department, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Riyadh, 11426 Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Basic Medical Sciences, Microbiology, Pathology and Laboratory Department, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Saeed, B T" sort="Saeed, B T" uniqKey="Saeed B" first="B. T." last="Saeed">B. T. Saeed</name><affiliation wicri:level="1"><nlm:aff id="Aff7">Cardiac Sciences Department, King Abdulaziz Medical City, Riyadh, 11426 Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Cardiac Sciences Department, King Abdulaziz Medical City, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Wahbi, A" sort="Wahbi, A" uniqKey="Wahbi A" first="A." last="Wahbi">A. Wahbi</name><affiliation wicri:level="1"><nlm:aff id="Aff8">Vascular Surgery, Department of Surgery, King Abdulaziz Medical City, Riyadh, 11426 Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Vascular Surgery, Department of Surgery, King Abdulaziz Medical City, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Saedy, A" sort="Saedy, A" uniqKey="Saedy A" first="A." last="Saedy">A. Saedy</name><affiliation wicri:level="1"><nlm:aff id="Aff9">Infectious Disease Section, Department of Medicine, King Abdulaziz Medical City, Riyadh, 11426 Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Infectious Disease Section, Department of Medicine, King Abdulaziz Medical City, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Aldabbagh, T" sort="Aldabbagh, T" uniqKey="Aldabbagh T" first="T." last="Aldabbagh">T. Aldabbagh</name><affiliation wicri:level="1"><nlm:aff id="Aff10">Intensive Care Unit, King Abdulaziz Medical City, Riyadh, 11426 Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Unit, King Abdulaziz Medical City, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Okaili, R" sort="Okaili, R" uniqKey="Okaili R" first="R." last="Okaili">R. Okaili</name><affiliation wicri:level="1"><nlm:aff id="Aff11">Neuro Radiology, Nuero Interventionalist, Medical Imaging Department, King Abdulaziz Medical City, Riyadh, 11426 Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Neuro Radiology, Nuero Interventionalist, Medical Imaging Department, King Abdulaziz Medical City, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Sadat, M" sort="Sadat, M" uniqKey="Sadat M" first="M." last="Sadat">M. Sadat</name><affiliation wicri:level="1"><nlm:aff id="Aff10">Intensive Care Unit, King Abdulaziz Medical City, Riyadh, 11426 Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Unit, King Abdulaziz Medical City, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Balkhy, H" sort="Balkhy, H" uniqKey="Balkhy H" first="H." last="Balkhy">H. Balkhy</name><affiliation wicri:level="1"><nlm:aff id="Aff12">Infection Prevention and Control Program, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center (KAIMRC), King Abdulaziz Medical City, Riyadh, 11426 Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Infection Prevention and Control Program, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center (KAIMRC), King Abdulaziz Medical City, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25600929</idno><idno type="pmc">4521086</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521086</idno><idno type="RBID">PMC:4521086</idno><idno type="doi">10.1007/s15010-015-0720-y</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000074</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000074</idno><idno type="wicri:Area/Pmc/Curation">000074</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000074</idno><idno type="wicri:Area/Pmc/Checkpoint">000310</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000310</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">000643</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000643</idno><idno type="wicri:Area/PubMed/Curation">000643</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000643</idno><idno type="wicri:Area/PubMed/Checkpoint">000629</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000629</idno><idno type="wicri:Area/Ncbi/Merge">000435</idno><idno type="wicri:Area/Ncbi/Curation">000435</idno><idno type="wicri:Area/Ncbi/Checkpoint">000435</idno><idno type="wicri:doubleKey">0300-8126:2015:Arabi Y:severe:neurologic:syndrome</idno><idno type="wicri:Area/Main/Merge">000918</idno><idno type="wicri:Area/Main/Curation">000916</idno><idno type="wicri:Area/Main/Exploration">000916</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Severe neurologic syndrome associated with Middle East respiratory syndrome corona virus (MERS-CoV)</title><author><name sortKey="Arabi, Y M" sort="Arabi, Y M" uniqKey="Arabi Y" first="Y. M." last="Arabi">Y. M. Arabi</name><affiliation><nlm:aff id="Aff1">Intensive Care Department, MC-1425, Respiratory Services, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center (KAIMRC), P.O. Box 22490, Riyadh, 11426 Kingdom of Saudi Arabia</nlm:aff><wicri:noCountry code="subfield">11426 Kingdom of Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Harthi, A" sort="Harthi, A" uniqKey="Harthi A" first="A." last="Harthi">A. Harthi</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Neuro Physiology Services, Neurology Division, Department of Medicine, King Abdulaziz Medical City, Riyadh, 11426 Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Neuro Physiology Services, Neurology Division, Department of Medicine, King Abdulaziz Medical City, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Hussein, J" sort="Hussein, J" uniqKey="Hussein J" first="J." last="Hussein">J. Hussein</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Neuro Radiology Section, Medical Imaging Department, King Abdulaziz Medical City, Riyadh, 11426 Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Neuro Radiology Section, Medical Imaging Department, King Abdulaziz Medical City, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Bouchama, A" sort="Bouchama, A" uniqKey="Bouchama A" first="A." last="Bouchama">A. Bouchama</name><affiliation wicri:level="1"><nlm:aff id="Aff4">Intensive Care Unit, Experimental Medicine Department, King Abdullah International Medical Research Center (KAIMRC), King Abdulaziz Medical City, Riyadh, 11426 Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Unit, Experimental Medicine Department, King Abdullah International Medical Research Center (KAIMRC), King Abdulaziz Medical City, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Johani, S" sort="Johani, S" uniqKey="Johani S" first="S." last="Johani">S. Johani</name><affiliation wicri:level="1"><nlm:aff id="Aff5">Microbiology, Pathology and Laboratory Medicine, King Abdulaziz Medical City, Riyadh, 11426 Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Microbiology, Pathology and Laboratory Medicine, King Abdulaziz Medical City, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Hajeer, A H" sort="Hajeer, A H" uniqKey="Hajeer A" first="A. H." last="Hajeer">A. H. Hajeer</name><affiliation wicri:level="1"><nlm:aff id="Aff6">Basic Medical Sciences, Microbiology, Pathology and Laboratory Department, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Riyadh, 11426 Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Basic Medical Sciences, Microbiology, Pathology and Laboratory Department, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Saeed, B T" sort="Saeed, B T" uniqKey="Saeed B" first="B. T." last="Saeed">B. T. Saeed</name><affiliation wicri:level="1"><nlm:aff id="Aff7">Cardiac Sciences Department, King Abdulaziz Medical City, Riyadh, 11426 Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Cardiac Sciences Department, King Abdulaziz Medical City, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Wahbi, A" sort="Wahbi, A" uniqKey="Wahbi A" first="A." last="Wahbi">A. Wahbi</name><affiliation wicri:level="1"><nlm:aff id="Aff8">Vascular Surgery, Department of Surgery, King Abdulaziz Medical City, Riyadh, 11426 Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Vascular Surgery, Department of Surgery, King Abdulaziz Medical City, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Saedy, A" sort="Saedy, A" uniqKey="Saedy A" first="A." last="Saedy">A. Saedy</name><affiliation wicri:level="1"><nlm:aff id="Aff9">Infectious Disease Section, Department of Medicine, King Abdulaziz Medical City, Riyadh, 11426 Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Infectious Disease Section, Department of Medicine, King Abdulaziz Medical City, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Aldabbagh, T" sort="Aldabbagh, T" uniqKey="Aldabbagh T" first="T." last="Aldabbagh">T. Aldabbagh</name><affiliation wicri:level="1"><nlm:aff id="Aff10">Intensive Care Unit, King Abdulaziz Medical City, Riyadh, 11426 Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Unit, King Abdulaziz Medical City, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Okaili, R" sort="Okaili, R" uniqKey="Okaili R" first="R." last="Okaili">R. Okaili</name><affiliation wicri:level="1"><nlm:aff id="Aff11">Neuro Radiology, Nuero Interventionalist, Medical Imaging Department, King Abdulaziz Medical City, Riyadh, 11426 Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Neuro Radiology, Nuero Interventionalist, Medical Imaging Department, King Abdulaziz Medical City, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Sadat, M" sort="Sadat, M" uniqKey="Sadat M" first="M." last="Sadat">M. Sadat</name><affiliation wicri:level="1"><nlm:aff id="Aff10">Intensive Care Unit, King Abdulaziz Medical City, Riyadh, 11426 Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Unit, King Abdulaziz Medical City, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Balkhy, H" sort="Balkhy, H" uniqKey="Balkhy H" first="H." last="Balkhy">H. Balkhy</name><affiliation wicri:level="1"><nlm:aff id="Aff12">Infection Prevention and Control Program, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center (KAIMRC), King Abdulaziz Medical City, Riyadh, 11426 Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Infection Prevention and Control Program, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center (KAIMRC), King Abdulaziz Medical City, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author></analytic><series><title level="j">Infection</title><idno type="ISSN">0300-8126</idno><idno type="eISSN">1439-0973</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Coronavirus Infections (diagnosis)</term><term>Coronavirus Infections (pathology)</term><term>Coronavirus Infections (virology)</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Middle East Respiratory Syndrome Coronavirus (isolation & purification)</term><term>Nervous System Diseases (diagnosis)</term><term>Nervous System Diseases (pathology)</term><term>Nervous System Diseases (virology)</term><term>Saudi Arabia</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Arabie saoudite</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification)</term><term>Humains</term><term>Imagerie par résonance magnétique</term><term>Infections à coronavirus (anatomopathologie)</term><term>Infections à coronavirus (diagnostic)</term><term>Infections à coronavirus (virologie)</term><term>Maladies du système nerveux (anatomopathologie)</term><term>Maladies du système nerveux (diagnostic)</term><term>Maladies du système nerveux (virologie)</term><term>Mâle</term><term>Sujet âgé</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Saudi Arabia</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Maladies du système nerveux</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Coronavirus Infections</term><term>Nervous System Diseases</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Infections à coronavirus</term><term>Maladies du système nerveux</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Coronavirus Infections</term><term>Nervous System Diseases</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Maladies du système nerveux</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term><term>Nervous System Diseases</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Arabie saoudite</term><term>Humains</term><term>Imagerie par résonance magnétique</term><term>Mâle</term><term>Sujet âgé</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Arabie saoudite</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Since the identification of the first case of infection with the Middle East respiratory syndrome corona virus (MERS-CoV) in Saudi Arabia in June 2012, the number of laboratory-confirmed cases has exceeded 941 cases globally, of which 347 died. The disease presents as severe respiratory infection often with shock, acute kidney injury, and coagulopathy. Recently, we observed three cases who presented with neurologic symptoms. These are so far the first reported cases of neurologic injury associated with MERS-CoV infection.</p></sec><sec><title>Methods</title><p>Data was retrospectively collected from three patients admitted with MERS-CoV infection to Intensive Care unit (ICU) at King Abdulaziz Medical City, Riyadh. They were managed separately in three different wards prior to their admission to ICU.</p></sec><sec><title>Finding</title><p>The three patients presented with severe neurologic syndrome which included altered level of consciousness ranging from confusion to coma, ataxia, and focal motor deficit. Brain MRI revealed striking changes characterized by widespread, bilateral hyperintense lesions on T2-weighted imaging within the white matter and subcortical areas of the frontal, temporal, and parietal lobes, the basal ganglia, and corpus callosum. None of the lesions showed gadolinium enhancement.</p></sec><sec><title>Interpretation</title><p>CNS involvement should be considered in patients with MERS-CoV and progressive neurological disease, and further elucidation of the pathophysiology of this virus is needed.</p></sec><sec><title>Electronic supplementary material</title><p>The online version of this article (doi:10.1007/s15010-015-0720-y) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zaki, Am" uniqKey="Zaki A">AM Zaki</name></author><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S van Boheemen</name></author><author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name></author><author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name></author><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Arabi, Ym" uniqKey="Arabi Y">YM Arabi</name></author><author><name sortKey="Arifi, Aa" uniqKey="Arifi A">AA Arifi</name></author><author><name sortKey="Balkhy, Hh" uniqKey="Balkhy H">HH Balkhy</name></author><author><name sortKey="Najm, H" uniqKey="Najm H">H Najm</name></author><author><name sortKey="Aldawood, As" uniqKey="Aldawood A">AS Aldawood</name></author><author><name sortKey="Ghabashi, A" uniqKey="Ghabashi A">A Ghabashi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Momattin, H" uniqKey="Momattin H">H Momattin</name></author><author><name sortKey="Mohammed, K" uniqKey="Mohammed K">K Mohammed</name></author><author><name sortKey="Zumla, A" uniqKey="Zumla A">A Zumla</name></author><author><name sortKey="Memish, Za" uniqKey="Memish Z">ZA Memish</name></author><author><name sortKey="Al Tawfiq, Ja" uniqKey="Al Tawfiq J">JA Al-Tawfiq</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marin, Se" uniqKey="Marin S">SE Marin</name></author><author><name sortKey="Callen, Dj" uniqKey="Callen D">DJ Callen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Elhassanien, Af" uniqKey="Elhassanien A">AF Elhassanien</name></author><author><name sortKey="Aziz, Ha" uniqKey="Aziz H">HA Aziz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nagel, Ma" uniqKey="Nagel M">MA Nagel</name></author><author><name sortKey="Mahalingam, R" uniqKey="Mahalingam R">R Mahalingam</name></author><author><name sortKey="Cohrs, Rj" uniqKey="Cohrs R">RJ Cohrs</name></author><author><name sortKey="Gilden, D" uniqKey="Gilden D">D Gilden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Desforges, M" uniqKey="Desforges M">M Desforges</name></author><author><name sortKey="Le Coupanec, A" uniqKey="Le Coupanec A">A Le Coupanec</name></author><author><name sortKey="Brison, E" uniqKey="Brison E">E Brison</name></author><author><name sortKey="Meessen Pinard, M" uniqKey="Meessen Pinard M">M Meessen-Pinard</name></author><author><name sortKey="Talbot, Pj" uniqKey="Talbot P">PJ Talbot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lau, Kk" uniqKey="Lau K">KK Lau</name></author><author><name sortKey="Yu, Wc" uniqKey="Yu W">WC Yu</name></author><author><name sortKey="Chu, Cm" uniqKey="Chu C">CM Chu</name></author><author><name sortKey="Lau, St" uniqKey="Lau S">ST Lau</name></author><author><name sortKey="Sheng, B" uniqKey="Sheng B">B Sheng</name></author><author><name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bergmann, Cc" uniqKey="Bergmann C">CC Bergmann</name></author><author><name sortKey="Lane, Te" uniqKey="Lane T">TE Lane</name></author><author><name sortKey="Stohlman, Sa" uniqKey="Stohlman S">SA Stohlman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yeh, Ea" uniqKey="Yeh E">EA Yeh</name></author><author><name sortKey="Collins, A" uniqKey="Collins A">A Collins</name></author><author><name sortKey="Cohen, Me" uniqKey="Cohen M">ME Cohen</name></author><author><name sortKey="Duffner, Pk" uniqKey="Duffner P">PK Duffner</name></author><author><name sortKey="Faden, H" uniqKey="Faden H">H Faden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arbour, N" uniqKey="Arbour N">N Arbour</name></author><author><name sortKey="Day, R" uniqKey="Day R">R Day</name></author><author><name sortKey="Newcombe, J" uniqKey="Newcombe J">J Newcombe</name></author><author><name sortKey="Talbot, Pj" uniqKey="Talbot P">PJ Talbot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yamashita, M" uniqKey="Yamashita M">M Yamashita</name></author><author><name sortKey="Yamate, M" uniqKey="Yamate M">M Yamate</name></author><author><name sortKey="Li, Gm" uniqKey="Li G">GM Li</name></author><author><name sortKey="Ikuta, K" uniqKey="Ikuta K">K Ikuta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xu, J" uniqKey="Xu J">J Xu</name></author><author><name sortKey="Zhong, S" uniqKey="Zhong S">S Zhong</name></author><author><name sortKey="Liu, J" uniqKey="Liu J">J Liu</name></author><author><name sortKey="Li, L" uniqKey="Li L">L Li</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Wu, X" uniqKey="Wu X">X Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Netland, J" uniqKey="Netland J">J Netland</name></author><author><name sortKey="Meyerholz, Dk" uniqKey="Meyerholz D">DK Meyerholz</name></author><author><name sortKey="Moore, S" uniqKey="Moore S">S Moore</name></author><author><name sortKey="Cassell, M" uniqKey="Cassell M">M Cassell</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S Perlman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gu, J" uniqKey="Gu J">J Gu</name></author><author><name sortKey="Gong, E" uniqKey="Gong E">E Gong</name></author><author><name sortKey="Zhang, B" uniqKey="Zhang B">B Zhang</name></author><author><name sortKey="Zheng, J" uniqKey="Zheng J">J Zheng</name></author><author><name sortKey="Gao, Z" uniqKey="Gao Z">Z Gao</name></author><author><name sortKey="Zhong, Y" uniqKey="Zhong Y">Y Zhong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bonavia, A" uniqKey="Bonavia A">A Bonavia</name></author><author><name sortKey="Arbour, N" uniqKey="Arbour N">N Arbour</name></author><author><name sortKey="Yong, Vw" uniqKey="Yong V">VW Yong</name></author><author><name sortKey="Talbot, Pj" uniqKey="Talbot P">PJ Talbot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arbour, N" uniqKey="Arbour N">N Arbour</name></author><author><name sortKey="Cote, G" uniqKey="Cote G">G Cote</name></author><author><name sortKey="Lachance, C" uniqKey="Lachance C">C Lachance</name></author><author><name sortKey="Tardieu, M" uniqKey="Tardieu M">M Tardieu</name></author><author><name sortKey="Cashman, Nr" uniqKey="Cashman N">NR Cashman</name></author><author><name sortKey="Talbot, Pj" uniqKey="Talbot P">PJ Talbot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arbour, N" uniqKey="Arbour N">N Arbour</name></author><author><name sortKey="Ekande, S" uniqKey="Ekande S">S Ekande</name></author><author><name sortKey="Cote, G" uniqKey="Cote G">G Cote</name></author><author><name sortKey="Lachance, C" uniqKey="Lachance C">C Lachance</name></author><author><name sortKey="Chagnon, F" uniqKey="Chagnon F">F Chagnon</name></author><author><name sortKey="Tardieu, M" uniqKey="Tardieu M">M Tardieu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gu, J" uniqKey="Gu J">J Gu</name></author><author><name sortKey="Korteweg, C" uniqKey="Korteweg C">C Korteweg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name></author><author><name sortKey="Mou, H" uniqKey="Mou H">H Mou</name></author><author><name sortKey="Smits, Sl" uniqKey="Smits S">SL Smits</name></author><author><name sortKey="Dekkers, Dh" uniqKey="Dekkers D">DH Dekkers</name></author><author><name sortKey="Muller, Ma" uniqKey="Muller M">MA Muller</name></author><author><name sortKey="Dijkman, R" uniqKey="Dijkman R">R Dijkman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Abbott, Ca" uniqKey="Abbott C">CA Abbott</name></author><author><name sortKey="Baker, E" uniqKey="Baker E">E Baker</name></author><author><name sortKey="Sutherland, Gr" uniqKey="Sutherland G">GR Sutherland</name></author><author><name sortKey="Mccaughan, Gw" uniqKey="Mccaughan G">GW McCaughan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Payne, Dc" uniqKey="Payne D">DC Payne</name></author><author><name sortKey="Iblan, I" uniqKey="Iblan I">I Iblan</name></author><author><name sortKey="Alqasrawi, S" uniqKey="Alqasrawi S">S Alqasrawi</name></author><author><name sortKey="Al Nsour, M" uniqKey="Al Nsour M">M Al Nsour</name></author><author><name sortKey="Rha, B" uniqKey="Rha B">B Rha</name></author><author><name sortKey="Tohme, Ra" uniqKey="Tohme R">RA Tohme</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Arabie saoudite</li></country></list><tree><noCountry><name sortKey="Arabi, Y M" sort="Arabi, Y M" uniqKey="Arabi Y" first="Y. M." last="Arabi">Y. M. Arabi</name></noCountry><country name="Arabie saoudite"><noRegion><name sortKey="Harthi, A" sort="Harthi, A" uniqKey="Harthi A" first="A." last="Harthi">A. Harthi</name></noRegion><name sortKey="Aldabbagh, T" sort="Aldabbagh, T" uniqKey="Aldabbagh T" first="T." last="Aldabbagh">T. Aldabbagh</name><name sortKey="Balkhy, H" sort="Balkhy, H" uniqKey="Balkhy H" first="H." last="Balkhy">H. Balkhy</name><name sortKey="Bouchama, A" sort="Bouchama, A" uniqKey="Bouchama A" first="A." last="Bouchama">A. Bouchama</name><name sortKey="Hajeer, A H" sort="Hajeer, A H" uniqKey="Hajeer A" first="A. H." last="Hajeer">A. H. Hajeer</name><name sortKey="Hussein, J" sort="Hussein, J" uniqKey="Hussein J" first="J." last="Hussein">J. Hussein</name><name sortKey="Johani, S" sort="Johani, S" uniqKey="Johani S" first="S." last="Johani">S. Johani</name><name sortKey="Okaili, R" sort="Okaili, R" uniqKey="Okaili R" first="R." last="Okaili">R. Okaili</name><name sortKey="Sadat, M" sort="Sadat, M" uniqKey="Sadat M" first="M." last="Sadat">M. Sadat</name><name sortKey="Saedy, A" sort="Saedy, A" uniqKey="Saedy A" first="A." last="Saedy">A. Saedy</name><name sortKey="Saeed, B T" sort="Saeed, B T" uniqKey="Saeed B" first="B. T." last="Saeed">B. T. Saeed</name><name sortKey="Wahbi, A" sort="Wahbi, A" uniqKey="Wahbi A" first="A." last="Wahbi">A. Wahbi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000916 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000916 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= CovidV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:4521086
|texte= Severe neurologic syndrome associated with Middle East respiratory syndrome corona virus (MERS-CoV)
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:25600929" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a CovidV1
| This area was generated with Dilib version V0.6.33. |  |